The Internet of Things (IoT) has received much attention over the past decade. With the rapid increase in the use of smart devices, we are now able to collect big data on a daily basis. The data we are gathering (and related problems) are becoming more complex and uncertain. Researchers have therefore turned to artificial intelligence (AI) to efficiently deal with the problems created by big data. This special issue deals with the technology and applications of AI in the IoT and is a forum for scientists, engineers, broadcasters, manufacturers, software developers, and other related professionals to discuss related issues. The topics addressed in this special issue include current research progress, real world applications, and security issues related to AI in IoT. The call for papers attracted a number of excellent submissions. After two round reviews, five papers were selected for publication. These papers are organized in three groups. The first group comprises one overview paper that outlines the technical progress of IoT. The second group comprises two papers addressing security issues in IoT. The last group comprises two papers that present some interesting real world applications that will benefit daily life.